4. Osteoarthritis

Osteoarthritis is the most common form of arthritis, affecting millions of people worldwide. It occurs when the protective cartilage on the ends of your bones wears down over time. Although osteoarthritis can damage any joint your hands, knee, hips, and spine. Some common risk factors for the development of knee osteoarthritis include female sex, obesity, older age, and previous knee injury.

Most individuals suffering from knee osteoarthritis report pain that is worse with use and better with rest. Other signs and symptoms of the disease may include stiffness that generally improves after 30-minutes of activity, swelling, crepitus (a grating sound or sensation), and limp. Pain from the condition may be treated with topical agents like capsaicin cream (Zostrix); oral anti-inflammatory agents such as acetaminophen (Tylenol) or ibuprofen (Advil); and injections directly into the knee joint with agents such as steroids or hyaluronic acid (Synvisc). The end-stage disease may have to be treated surgically with total knee replacement.