9. Other Possible Explainations

If you cannot point to any of the reasons on this list as the cause of your eye color transformation, it could also be due to things like a traumatic eye injury, allergies, liver problems, or even cancer.

A reddening of the whites in your eyes, accompanied by itchiness and dryness could signal undiagnosed allergies. Alternatively, if the whites of the eye are turning yellow, it could be an indication of a more serious problem like liver disease. Rachel Bishop, MD, chief of the consult service section of the National Eye Institute, also says that change in a single eye could be the result of melanoma of the iris.