3. Fuchs Uveitis Syndrome

Fuchs heterochromic uveitis/Fuchs heterochromic iridocyclitis, or more commonly known as Fuchs uveitis syndrome, is another condition where a person has two different colored eyes. But unlike heterochromia, here only one eye is affected and it isn’t exactly harmless. In fact, it can cause the uvea, located in the middle of the eye, to become inflamed.

“This typically leads to the lightening of the iris of the affected eye, although in some cases the condition causes iris darkening. The end result is a difference in eye color between the eyes or heterochromia,” explains LiveStrong.

They also say that eye color change is one of the first symptoms of the disease, and that people with the condition are more likely to develop cataracts or glaucoma.